Novel Sequence Determinants in Peroxisome Proliferator Signaling

ACCELERATED COMMUNICATION Diclofenac Antagonizes Peroxisome Proliferator-Activated Receptor- Signaling

Although nonsteroidal anti-inflammatory drugs (NSAIDs) are used as cancer chemopreventative agents, their mechanism is unclear because NSAIDs have cyclooxygenase-independent actions. We investigated an alternative target for NSAIDs, peroxisome proliferator-activated receptor(PPAR ), activation of which decreases cancer cell proliferation. NSAIDs have been shown to activate this receptor, but on...

Relaxin signaling activates peroxisome proliferator-activated receptor gamma.

Relaxin is a polypeptide hormone that triggers multiple signaling pathways through its receptor RXFP1 (relaxin family peptide receptor 1). Many of relaxin's functions, including vascular and antifibrotic effects, are similar to those induced by activation of PPARgamma. In this study, we tested the hypothesis that relaxin signaling through RXFP1 would activate PPARgamma activity. In cells overex...

Antagonizing Peroxisome Proliferator

Peroxisome Proliferator-Activated Receptor

Peroxisome Proliferator-activated Receptors

Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-activated nuclear hormone receptor superfamily of transcription factors that includes receptors for steroids, thyroid hormone, retinoic acid, and vitamin D. Upon activation in the cytoplasm, PPARs heterodimerize with retinoid X receptors (RXR) and form a complex that translocates to the nucleus and regulates gene expr...